Omkareshwar is easily accessible by road and is located 73 km from Khandwa, 86 km from Indore, 114 km from Dewas, 133 km from Ujjain, 222 km from Jalgaon, 268 km from Bhopal, 334 km from Vidisha, 376 km from Vadodara, 446 km from Nagpur, 576 km from Pune, and 576 km from Mumbai. The Madhya Pradesh State Road Transport Corporation (MPRTC) provides bus services from Omkareshwar to other cities

Omkareshwar has its own railway station, which is located 12 km from the city. The station, Omkareshwar Road, is connected to various cities such as New Delhi, Bangalore, Mysore, Lucknow, Chennai, Kanyakumari, Puri, Ahmedabad, Jaipur, and Ratlam. The major railway stations near Omkareshwar are Indore and Khandwa